Adobe Lightroom uses database files. Like all database files, they should not be synced, and special measures need to be taken to back them up. Like any database, backing it up directly will not work, nor should its ancillary files be backed up. For example, the previews for your photos flap a lot when Lightroom is in use, as well as take up a lot of space. Nor do they even need to be backed up, because those previews are rebuilt by Lightroom.
Instead, take advantage of Lightroom's built in backup function, and have SpiderOak One or Groups back up only the backup file that Lightroom periodically creates for this purpose. That file can be safely backed up by SpiderOak, and Lightroom for its part will be able to use it should recovery be needed.
Like all database files, Lightroom files should not be synced.